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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

  • Nitrates
  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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  • Back pain

Less common side effects but serious side effects include visual disturbances, hearing changes, or prolonged erections.

Does This Drug Work?

Sildenafil does not work immediately. To achieve better results, your doctor may increase the dose to 50mg or decrease to 25mg, depending on your underlying medical conditions.

Is this Medication Safe?

Healthcare professionals have experience of the drug's safety in the treatment of ED. Report back to your doctor or pharmacist, if necessary.

1. Introduction

The first systematic review and meta-analysis of the use of sildenafil citrate as a treatment for erectile dysfunction has been published. However, it is difficult to define the characteristics of the studies with which the use of sildenafil citrate could be evaluated. This article, therefore, focuses on a number of studies that used sildenafil citrate for the treatment of erectile dysfunction. Furthermore, the aim of the article is to provide a new perspective on the use of sildenafil citrate as a treatment for erectile dysfunction. The present article discusses the use of sildenafil citrate in clinical practice. It also discusses the potential impact on the quality of the studies in the literature, the limitations of the studies, and the selection of studies by the inclusion/exclusion criteria. Finally, the article concludes that the use of sildenafil citrate as a treatment for erectile dysfunction has been extensively studied.

2. The Study Characteristics

The search was conducted in electronic databases, including the Cochrane Library, MEDLINE, EMBASE, PsycINFO, Cochrane Database of Systematic Reviews, and the Cochrane Database of Systematic Reviews. The full texts of the identified studies were obtained from each of the following databases: reference lists of retrieved studies; randomised clinical trials; observational studies; prospective studies; controlled clinical trials; and meta-analyses.

Uses of Sildenafil

Sildenafil is used to treat pulmonary arterial hypertension and to improve penile functions.

Therapeutic Category

Sildenafil: Phosphodiesterase type 5 (PDE 5) inhibitors

How Sildenafil works

Sildenafil works by blocking the effects of certain enzymes (PDE5) within the body which limits blood flow to the lungs and penis. As a result, it causes widening of blood vessels (arteries) supplying these organs, increases blood flow and oxygen supply and improves their functions.

Common side effects of Sildenafil

  • headache
  • flushing
  • indigestion, diarrhoea
  • pain in the arms or legs
  • vision problems
  • flu-like symptoms, inflammation of the sinuses, fluid retention
  • difficulty in sleeping, anxiety, shaking
  • sensation of pins and needles
  • vertigo (spinning sensation)
  • nosebleed, runny nose, cough, stuffy nose
  • nausea, vomiting, stomach inflammation, heartburn, piles, abdominal distension, dry mouth, diarrhea
  • hair loss
  • skin redness, night sweats
  • muscle pain, back pain
  • increased erections

When to consult your doctor

Consult your doctor if you experience:

  • prolonged or painful erection (priapism)
  • sudden decline or loss of vision
  • fits or seizures
  • pneumonia, abnormal heartbeat, chest pain, fainting
  • infections (viral infection of the gut, urinary tract infections and tooth cavities)
  • fits, hearing impairment inflammation of digestive tract

Health Tips for Sildenafil

  • Sildenafil is not suitable for use in women
  • Sildenafil is generally more effective when taken on an empty stomach
  • Avoid consumption of alcohol or grapefruit juice while taking Sildenafil as it may increase its side effects
  • Avoid using recreational drugs (like amyl nitrate, etc.) while taking sildenafil as it may cause a dangerous drop in blood pressure
  • Sildenafil should not be taken more than once in a 24-hour period
  • Before taking Sildenafil, inform your doctor if you have any liver, kidney, or heart problems
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Note:Healthcare professionals should stop taking Sildenafil and related medications ASAP and seek medical attention if they occur.

Note: Health professionals should stop taking Sildenafil and related medications ASAP and seek medical attention if they occur.

Share Share LoginWarning/PrecautionsDo not take Sildenafil if you are taking nitrates, guanylate cyclase stimulators (for high blood pressure), or other PDE 5 inhibitors (such as (emtricitabine) or (ciclopram) for premature coronary artery disease). PDE 5 inhibitors can increase the risk of a heart attack or stroke. Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.

Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.

esar disfunctions
  • Sildenafil can affect the shape of erections by increasing blood flow to the penis.
  • Vericiguat can mask the presence of Sildenafil.
  • If you are allergic to Sildenafil or any other tadalafil component, it is recommended that it not be used. Let your doctor know if you’re using any other medications to treat ED or ED, as long as they did not affect you.
  • Avoid Sildenafil with nitrates used for treating chest pain.
  • If you’re taking an alpha-blocker for an enlarged prostate (like itraconazole or ketoconazole), it may cause pressure to be taken if you’re also taking an alpha-blocker for an enlarged prostate (like doxazosin or tamsulosin).
Takecrehensive Effects
  • Sildenafil can interfere with the final results of sexual intercourse.
  • Alpha-blockers can cause a dangerous drop in blood pressure when used with nitrates used for treating chest pain.
  • If you are also taking an alpha-blocker for an enlarged prostate (like itraconazole or ketoconazole), it can cause dizziness or fainting by themselves.
  • Avoid Sildenafil with tamsulosin.
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Recommended Dosage:A doctor may recommend a starting dose of Sildenafil as a second line of treatment after initial diagnosis.

Electronic medical providers (EHCs) can write prescriptions for Sildenafil based on factors like dosage, medical history, and other medications being taken. These EHCs may require a doctor’s approval to work.

INDICATIONS

Sildenafil is used to treat erectile dysfunction (ED) and pulmonary hypertension (high blood pressure in the lungs).

Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. It can be caused by various factors, including underlying health conditions (like heart disease, diabetes, or liver or kidney disease), medications (like Sildenafil), and an underlying medical condition (such as diabetes or high blood pressure).

If you’re taking Sildenafil to treat ED and have underlying health conditions, it is recommended that you start with a low dose and gradually increase it.

Vericiguat (e.g.